You've read novels or seen movies...
...where the hero is a scientist who works like a detective to find the source of a disease and/or the cure?
Well, here is that scientist: Maurice Hilleman. He died a couple of days ago at the age of 85.
Listen to this from his New York Times obituary:
Well, here is that scientist: Maurice Hilleman. He died a couple of days ago at the age of 85.
Listen to this from his New York Times obituary:
Much of modern preventive medicine is based on Dr. Hilleman's work, though he never received the public recognition of Salk, Sabin or Pasteur. He is credited with having developed more human and animal vaccines than any other scientist, helping to extend human life expectancy and improving the economies of many countries.
Dr. Hilleman probably saved more lives than any other scientist in the 20th century, said two medical leaders, Dr. Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases, and Dr. Paul A. Offit, chief of infectious diseases at Children's Hospital in Philadelphia.
"The scientific quality and quantity of what he did was amazing," Dr. Fauci said. "Just one of his accomplishments would be enough to have made for a great scientific career. One can say without hyperbole that Maurice changed the world with his extraordinary contributions in so many disciplines: virology, epidemiology, immunology, cancer research and vaccinology."
Dr. Hilleman developed 8 of the 14 vaccines routinely recommended: measles, mumps, hepatitis A, hepatitis B, chickenpox, meningitis, pneumonia and Haemophilus influenzae bacteria (which brings on a variety of symptoms, including inflammation of the lining of the brain and deafness). He also developed the first generation of a vaccine against rubella or German measles. The vaccines have virtually vanquished many of the once common childhood diseases in developed countries.
Dr. Hilleman overcame immunological obstacles to combine vaccines so that one shot could protect against several diseases, like the MMR vaccine for measles, mumps and rubella.
He developed about 40 experimental and licensed animal and human vaccines, mostly with his team from Merck of Whitehouse Station, N.J. His role in their development included lab work as well as scientific and administrative leadership. His colleagues said he routinely credited others for their roles in advances.
Vaccine development is complex, requiring an artistry to safely produce large amounts of weakened live or dead micro-organisms. "Maurice was that artist: no one had the green thumb of mass production that he had," Dr. Offit said.
The hepatitis B vaccine, licensed in 1981, is credited as the first to prevent a human cancer: a liver cancer, known as a hepatoma, that can develop as a complication of infection from the hepatitis B virus.
One of Dr. Hilleman's goals was to develop the first licensed vaccine against any viral cancer. He achieved it in the early 1970's, developing a vaccine to prevent Marek's disease, a lymphoma cancer of chickens caused by a member of the herpes virus family. Preventing the disease helped revolutionize the economics of the poultry industry.
Dr. Hilleman's vaccines have also prevented deafness, blindness and other permanent disabilities among millions of people, a point made in 1988 when President Ronald Reagan presented him with the National Medal of Science, the nation's highest scientific honor.
Dr. Hilleman also discovered several viruses and made fundamental discoveries about the way the influenza virus mutates.
Because scientific knowledge about viruses was so limited when he began his career, Dr. Hilleman said that trial and error, sound judgment and luck drove much of his research.
Comments